They'll be shitloads of these lists in the next few months so I thought I'd jump in with one:
Ellie Goulding - http://www.myspace.com/elliegoulding Not so much of a choice, as an automatic.
Local Natives - http://www.myspace.com/localnatives Debut album out already and it's great, you really should have it. They'll do well in the Fleet Foxes market.
Delphic - http://www.myspace.com/delphic Album out in January. Expect the Manchester electronic-indie three-piece to get quite popular.
Marina & the Diamonds - http://www.myspace.com/marinaandthediamonds Plain pop music that will be big.
Hurts - http://www.myspace.com/ithurts Not my thing, but tipped for a massive label push.
Drake - http://www.myspace.com/thisisdrake Rapper already huge in America.
Esben & the Witch - http://www.myspace.com/esbenandthewitch Scary stuff, a bit like Portishead.
Stornoway - http://www.myspace.com/stornoway Already been on Jools Holland. Folk & harmonies.
Tinie Tempah - http://www.myspace.com/tinielegend UK hip-hop.
Bicycle Thieves - http://www.myspace.com/bicyclethievesuk Dark indie.
SOME SMALLER ACTS TO LOOK OUT FOR;
Broken Spindles, Freelance Whales, Real Estate, Darwin Deez, Surfer Blood, Goldheart Assembly, Everyhting Everything, Dum Dum Girls, Music Go Music, Free Energy, Band Of Skulls, I Blame Coco, Frankie & The Heartstrings, Detatchments, Chew Lips, The Cheek, Dutch Uncles, Lost Knives, Two Door Cinema Club.